vaults: novel cell particles
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Vaults for Scientists (who are Big Kids)

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Vaults are large cytoplasmic ribonucleoprotein (RNP) particles found in nearly all eukaryotic cells. They were first described in 1986. Because the particle is abundant in all cells of higher eukaryotics and highly conserved throughout evolution, it is likely that vaults have an important cellular function.

History

Composition of the Vault

Vault Structure

CryoEm Structure

CryoEm Structure - Part 2

Vault RNA (vRNA)

vRNA Gene Transcription

Species Distribution

Vault Components

Dictyostelium MVP Mutants

Cellular Localization

Vaults and Nuclear Pores

Multidrug Resistance

Tep1

VPARP

Vault Assembly

Designer Vaults

Designer Vaults - Part 2

Delivering Vaults to Cells

Targeting Vaults to Cell Receptors

Delivering Vaults to the Cytoplasm

Vaults as "Smart Adjuvants"

Vaults and Cell Signaling

Concluding Remarks

References

Definitions

Frequently Asked Questions

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