vaults: novel cell particles

Scientists: References


Vault Papers (referenced at this web site)

Chugani, D. C., Kedersha, N. L. and Rome, L. H. (1991) Vault immunofluorescence in brain: New insights regarding the origin of microglia. J Neurosci 11, 256-268.

Chugani, D. C., Rome, L. H. and Kedersha, N. L. (1993) Localization of vault particles to the nuclear pore complex. J Cell Sci 106, 23-9. PubMed Link

Hamill, D.R. and Suprenant, K.A. (1997) Characterization of the Sea Urchin Major Vault Protein - a Possible Role For Vault Ribonucleoprotein Particles in Nucleocytoplasmic Transport. Developmental Biology 190, 117-128.

Harringon et al. (1997) A mammalian telomerase-associated protein Science 275, 973-977.

Herrmann, C., Zimmerman, H. and Volknandt, W. (1997) Gene 188, 85-90.

Izquierdo, M. A. et al. (1995) J Natl Cancer Inst.

Izquierdo, M.A., Scheffer, G.L., Flens, M.J., Shoemaker, R.H., Rome, L.H. and Scheper, R.J. (1996) Relationship of LRP-human major vault protein to in vitro and clinical resistance to anticancer drugs. Cytotechnology 19, 191-197.

Kedersha, N.L. and Rome, L.H. (1986a) Preparative agarose gel electrophoresis for the purification of small organelles and particles. Anal Biochem 156, 161-170.

Kedersha, N. L. and Rome, L. H. (1986b) Isolation and characterization of a novel ribonucleoprotein particle: Large structures contain a single species of small RNA. J Cell Biol 103, 699-709. PubMed Link

Kedersha, N. L., Miquel, M. C., Bittner, D. and Rome, L. H. (1990) Vaults. II. Ribonucleoprotein structures are highly conserved among higher and lower eukaryotes. J Cell Biol 110, 895-901. PubMed Link

Kedersha, N. L. and Rome, L. H. (1990) Large cytoplasmic RNP's that associate with cytoskeletal elements. Mol Biol Reports 14, 121-122.

Kedersha, N. L., Heuser, J. E., Chugani, D. C. and Rome, L. H. (1991) Vaults. III. Vault Ribonucleoprotein Particles Open into Flower-like Structures with Octagonal Symmetry. J Cell Biol 112, 225-35. PubMed Link

Kickhoefer, V.A. Garcia, Y. Mikyas, Y. Johansson, E. Zhou, J. C. Raval-Fernandes, S. Minoofar, P. Zink, J. I. Dunn, B. Stewart, P. L. and Rome, L. H. (2005) Engineering of Vault Nanocapsules with Enzymatic and Fluorescent Properties. Proc. Natl. Acad. Sci. USA 102: 4348-52.

Kickhoefer, V.A., Poderycki, M.J., Chan, E.K. and Rome, L.H. (2002) The La RNA-binding protein interacts with the vault RNA and is a vault-associated protein. J. Biol. Chem. 277, 41282-4186.

Kickhoefer, V. A., Searles, R.P., Kedersha, N.L., Garber, M.E., Johnson, D.L. and Rome, L.H. (1993) Vault RNP particles from rat and bullfrog contain a related small RNA that is transcribed by RNA polymerase III. J Biol Chem 268, 7868-73. PubMed Link

Kickhoefer, V. A. and Rome, L. H. (1994) The sequence of a cDNA encoding the major vault protein from Rattus norvegicus. Gene 151, 257-60.

Kickhoefer, V.A., Rajavel, K.S., Scheffer, G.L., Dalton, W.S., Scheper, R.J., and Rome, L.H. (1998) Vaults are up-regulated in multidrug resistant cancer cell lines. J Biol Chem 273, 8971-8974. PubMed Link

Kickhoefer, V. A., Stephen, A.G., Harrington, L., Robinson, M.O. and Rome, L. H. (1999a) Vaults and Telomerase Share a Common Subunit, TEP1. J Biol Chem 274, 32712-32717. PubMed Link

Kickhoefer, V. A., Siva, A.C., Kedersha, N.L., Inman, E.M., Ruland, C., Streuli, M. and Rome, L. H. (1999b) The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase. J Cell Biol 146, 917-928. PubMed Link

Kickhoefer, V.A., Liu, Y., Kong, L.B., Snow, B.E., Stewart, P.L , Harrington, L., and Rome, L.H. (2001) The telomerase/vault-associated protein TEP1 is required for vault RNA stability and its association with the vault particle. J. Cell Biol. 152, 157-164.

Kickhoefer, V. A. unpublished.

Kong, L.B., Siva, A.C., Rome, L.H. and Stewart, P.L. (1999) Structure of the vault, a ubiquitious cellular component. Structure 7, 371-379.

Kong, L.B., Siva, A.C., Kickhoefer, V.A., Rome, L.H., and Stewart, P.L. (2000) RNA location and modeling of a WD40 repeat domain within the vault. RNA 6, 1-11.

Liu, Y., Snow, B.E., Hande, M.P., Baerlocher, G., Kickhoefer, V.A., Yeung, D., Wakeham, A., Itie, A., Siderovski, D.P., Lansdorp, P.M., Robinson, M.O., and Harrington, L. (2000) The telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivo. Mol. Cell Biol. 20, 8178-8184.

Mikyas, Y., Makabi, M., Raval-Fernandes, S., Harrington, L., Kickhoefer, V. A., Rome, L.H. and Stewart P. L. (2004) Cryoelectron Microscopy Imaging of Recombinant and Tissue Derived Vaults: Localization of the MVP N Termini and VPARP. J. Mol. Biol. 344, 91-105.

Scheffer, G.L., Wijngaard, P.L.J., Flens, M.J., Izquierdo, M.A., Slovak .M., Meijer, C., Clevers, H.C. and Scheper, R.J. (1995) The Drug Resistance-Related Protein Lrp Is the Human Major Vault Protein. Nature Medicine 1, 578-582. PubMed Link

Scheper, R.J., Broxterman, H.J., Scheffer, G.L., Kaaijk, P., Dalton, W.S., van Heijningen, T.H., van Kalken, C.K., Slovak, M.L., de Vries, E.G., van der Valk, P. and et al. (1993) Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance. Cancer Research 53, 1475-9.

Siva, A.C., Raval-Fernandes, S., Stephen, A.G., LaFemina, M.J., Scheper, R.J., Kickhoefer, V.A., and Rome, L.H. (2001) Upregulation of vaults may be necessary but not sufficient for multidrug resistance. Int. J. Cancer 92, 195-202.

Stephen, A.G., Raval-Fernandes, S., Huynh, T., Torres, M., Kickhoefer, V.A. and Rome, L.H. (2001) Assembly of vault-like particles in insect cells expressing only the major vault protein J. Biol. Chem. 276: 23217-23220.

Vasu, S. K., Kedersha, N. L. and Rome, L. H. (1993) cDNA cloning and disruption of the major vault protein alpha gene (mvpA) in Dictyostelium discoideum. J Biol Chem 268, 15356-60. PubMed Link

Vasu, S. K. and Rome, L. H. (1995) Dictyostelium vaults: Disruption of the major proteins reveals growth and morphological defects and uncovers a new associated protein. J Biol Chem 270, 16588-16594. PubMed Link

Vilalta, A., Kickhoefer, V. A., Rome, L. H. and Johnson, D. L. (1994) The rat vault RNA gene contains a unique RNA polymerase III promoter composed of both external and internal elements that function synergistically. J Biol Chem 269, 29752-9.

More Vault Papers and Vault-Related Papers (some referenced at this site)

Abbondanza, C., Rossi, V., Roscigno, A., Gallo, L., Belsito, A., Piluso, G., Medici, N., Nigro, V., Molinari, A.M., Moncharmont, B. and Puca, G.A. (1998) Interaction of Vault Particles With Estrogen Receptor in the Mcf-7 Breast Cancer Cell. Journal of Cell Biology 141, 1301-1310.

Akey, C. W. (1995) J Mol Biol 248, 273-93.

Flens, M.J., Scheffer, G.L., Vandervalk, P., Broxterman, H.J., Eijdems, E., Huysmans, A., Izquierdo, M.A. and Scheper, R.J. (1997) Identification of Novel Drug Resistance-Associated Proteins By a Panel of Rat Monoclonal Antibodies. International Journal of Cancer 73, 249-257.

Herrmann, C., Golkaramnay, E., Inman, E., Rome, L., and Volknandt, W.: Recombinant Major Vault Protein is Targeted to Neuritic Tips of PC12 Cells. (1999) J Cell Biol 144, 1163-1172.

Herrmann, C., Kellner, R. and Volknandt, W. (1998) Major Vault Protein of Electric Ray Is a Phosphoprotein. Neurochemical Research 23, 39-46.

Izquierdo, M.A., Shoemaker, R.H., Flens, M.J., Scheffer, G.L., Wu, L., Prather, T.R. and Scheper, R.J. (1996) Overlapping Phenotypes of Multidrug Resistance Among Panels of Human Cancer-Cell Lines. International Journal of Cancer 65, 230-237.

Izquierdo, M.A., Scheffer, G.L., Flens, M.J., Giaccone, G., Broxterman, H.J., Meijer, C., Vandervalk, P. and Scheper, R.J. (1996) Broad Distribution of the Multidrug Resistance-Related Vault Lung Resistance Protein in Normal Human Tissues and Tumors. American Journal of Pathology 148, 877-887.

Izquierdo, M.A., Scheffer, G.L., Schroeijers, A.B., de Jong, M.C. and Scheper, R.J. (1998) Vault-related resistance to anticancer drugs determined by the expression of the major vault protein LRP. Cytotechnology 27, 137-148.

Jaeger, J. A., Turner, D. H. and Zuker, M. (1990) Methods Enzymol 183, 281-306.

Kitazono, M., Sumizawa, T., Takebayashi, Y., Chen, Z.S., Furukawa, T., Nagayama, S., Tani, A., Takao, S., Aikou, T. and Akiyama, S. (1999) Multidrug resistance and the lung resistance-related protein in human colon carcinoma SW-620 cells. Journal of the National Cancer Institute. 91, 1647-1653.

Laurencot, C.M., Scheffer, G.L., Scheper, R.J. and Shoemaker, R.H. (1997) Increased LRP mRNA Expression Is Associated With the MDR Phenotype in Intrinsically Resistant Human Cancer Cell Lines. International Journal of Cancer 72, 1021-1026.

Mehlin, H., Daneholt, B. and Skoglund, U. (1995) J Cell Biol 129, 1205-16.

Nakayama, J., Saito, M., Nakamura, H., Matsuura, A. & Ishikawa, F. (1997) TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family. Cell 88, 875-884.

Roninson, I. B. (1991) (Roninson, I. B., ed.), Plenum Press.

Schroeijers, A.B., Siva, A.C., Scheffer, G.L., de Jong, M.C., Bolick, S.C.E., Dukers, D.F., Slootstra, J.W., Meloen, R.H., Wiemer, E., Kickhoefer, V.A., Rome, L.H., and Scheper, R.J. (2000) The Mr 193,000 vault protein is up-regulated in multidrug-resistant cancer cell lines. Cancer Research 60, 1104-1110.

Unwin, P. N. T. and Milligan, R. A. (1982) J Cell Biol 93, 63-75.

Willis, I. M. (1993) Eur J Biochem 212, 1-11.

Hu, Y., Stephen, A.G., Cao, J., Tanzer, L.R., Slapak, C.A., Harrison, S.D., Devanarayan, V., Dantzig, A.H., Starling, J.J., Rome, L.H. and Moore, R.E. (2002) A Very Early Induction of Major Vault Protein Is Accompanied By Increased Drug Resistance in U-937 Cells. Int J. Cancer 97, 149-156.

Kickhoefer, V. Emre, N., Stephen, A., Poderycki, M., and Rome, L. (2003) Identification of conserved vault RNA expression elements and a non-expressed mouse vault gene. Gene 309, 65-70.

Emre, N. Raval-Fernandes, S. Kickhoefer, V.A. and Rome, L.H. (2004) Analysis of MVP and VPARP promoters indicates a role for chromatin remodeling in the regulation of MVP. Biochim Biophys Acta. 1678, 33-46.

Liu, Y., Snow, B.E., Kickhoefer, V.A., Erdmann, N., Zhou, W., Wakeham, A., Gomez, W., Rome L.H. and Harrington L. (2004) Vault protein VPARP is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivo. Mol. Cell. Biol. 12, 5314-5323.

Poderycki, M. J., Rome, L. H., Harrington, L. and Kickhoefer V.A. (2005) The p80 homology region of TEP1 is sufficient for its association with the telomerase and vault RNAs, and the vault particle. Nucleic Acids Research 33, 893-902.

Slesina, M., Inman, E.M., Rome, L.H. and Volknandt, W. (2005) Nuclear localization of the major vault protein in U373 cells, Cell and Tissue Research 321, 97-104.

Raval-Fernandes, S., Kickhoefer, V.A., Kitchen, C. and Rome, L.H. (In Press) Increased susceptibility of vault poly (ADP-ribose) polymerase deficient mice to carcinogen-induced tumorigenesis. Cancer Research.

Yu,Z., Fatouhi-Ardakani. N., Wu, L., Maoui, M., Wang, S., Banville, D. and Shen, S.H. (2002) PTEN associates with the vault particles in HeLa cells. J Biol Chem 277, 40247?40252.

Myers, M. P., Stolarov, J. P., Eng, C., Li, J., Wang, S. I., Wigler, M. H., Parsons, R., and Tonks, N. K. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 9052-9057.

Tamura, M., Gu, J., Matsumoto, K., Aota, S., Parsons, R., and Yamada, K. (1998) Science 280, 1614-1617.

Chung, J.H., Ginn-Pease, M.E. and Eng, C. (2005) Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has nuclear localization signal-like sequences for nuclear import mediated by major vault protein. Cancer Res. 65, 4108-4116.

Mossink, M.H., van Zon, A., Franzel-Luiten, E., Schoester, M., Kickhoefer, V.A., Scheffer, G.L., Scheper, R.J., Sonneveld, P. and Wiemer, E.A. (2002) Disruption of major vault protein (MVP/LRP) gene does not induce hypersensitivity to cytostatics. Cancer Res 62, 7298?7304.

Kolli, S., Zito, C.I., Mossink, M.H., Wiemer, E.A. and Bennett, A.M. (2004) The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling. J Biol Chem 279, 29374?29385.

Yi, C., Li, S., Chen, X., Wiemer, E.A., Wang, J., Wei, N. and Deng, X.W. (2005) Major vault protein, in concert with constitutively photomorphogenic 1, negatively regulates c-Jun-mediated activator protein 1 transcription in mammalian cells. Cancer Res. 65, 5835-40.

Yi, C.., Li, S., Wang, J., Wei, N. and Deng, X.W. (2006) Affinity purification reveals the association of WD40 protein constitutive photomorphogenic 1 with the hetero-oligomeric TCP-1 chaperonin complex in mammalian cells. Int. J. Biochem. Cell Biol. 38, 1076-1083.

Krull, J. Thyberg, B. Bjorkroth, H.R. Rackwitz and V.C. Cordes, (2004) Nucleoporins as components of the nuclear pore complex core structure and tpr as the architectural element of the nuclear basket. Molecular Biology of the Cell 15, 4261?4277.

Steiner, E., Holzmann, K., Pirker, C., Elbling, L., Micksche, M., Sutterluty, H., and Berger, W. (2006) The major vault protein is responsive to and interferes with interferon--mediated STAT1 signals. J. Cell Sci. 119: 459-469.

Kim, E., Lee, S., Mian, M.F., Yun, S.U., Song, M., Yi, K.S., Ryu, S.H. and Suh, P.G. (2006) Crosstalk between Src and major vault protein in epidermal growth factor-dependent cell signalling. FEBS J. 273, 793-804.

Gopinath S.C., Matsugami, A., Katahira, M., and Kumar, P.K. (2005) Human vault-associated non-coding RNAs bind to mitoxantrone, a chemotherapeutic compound. Nucleic Acids Res. 33, 4874-4881.

Huffman, K.E., and Corey, D.R. (2005) Major vault protein does not play a role in chemoresistance or drug localization in a non-small cell lung cancer cell line. Biochemistry 44, 2253-2261.

van Zon, A., Mossink, M.H., Schoester, M., Scheper, R.J., Sonneveld, P., and Wiemer, E.A. (2004) Efflux kinetics and intracellular distribution of daunorubicin are not affected by major vault protein/lung resistance-related protein (vault) expression. Cancer Res. 64, 4887-4892.

Hamill DR & Supernant KA (1997) Characterization of the sea urchin major vault protein: a possible role of vault ribonucleoprotein particles in nucleocytoplasmic transport. Dev Biol 190, 117?128.

Ehrnsperger C & Volkandt W (2001) Major vault protein is a substrate of endogenous protein kinases in CHO and PC12 cells. Biol Chem 382, 1463?1471.

Van Zon A, Mossink MH, Schoester M, Scheffer GL, Scheper RJ, Sonneveld P & Wiemer EA (2002) Structural domains of Vault proteins: a role for the coiled-coil domain in vault assembly. Biochem Biophys Res Comm 291, 535?541.

Steiner, E., Holzmann, K., Pirker, C., Elbling, L., Micksche, M. and Berger, W. (2004). SP-transcription factors are involved in basal MVP promoter activity and its stimulation by HDAC inhibitors. Biochem. Biophys. Res. Commun. 317, 235-243.

Zheng, C. L., Sumizawa, T., Che, X. F., Tsuyama, S., Furukawa, T., Haraguchi, M., Gao, H., Gotanda, T., Jueng, H. C., Murata, F. et al. (2005). Characterization of MVP and VPARP assembly into vault ribonucleoprotein complexes. Biochem. Biophys. Res. Commun. 326, 100-107.

Kozlov, G., Vavelyuk, O., Minailiuc, O., Banville, D., Gehring, K. and Ekiel, I. (2006) Solution structure of a two-repeat fragment of major vault protein. J. Mol. Biol. 356, 444-52.

van Zon, A., Mossink, M.H., Houtsmuller, A.B., Schoester, M., Scheffer, G.L., Scheper, R.J., Sonneveld, P. and Wiemer, E.A. (2006) Vault mobility depends in part on microtubules and vaults can be recruited to the nuclear envelope. Exp. Cell Res. 312, 245-55.

Chung, J.H. and Eng, C. (2005) Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis. Cancer Res. 65, 8096-100.

Stewart PL, Makabi M, Lang J, Dickey-Sims C, Robertson AJ, Coffman JA, Suprenant KA. (2005) Sea urchin vault structure, composition, and differential localization during development. BMC Dev Biol. 5, 3.

Zheng CL, Sumizawa T, Che XF, Tsuyama S, Furukawa T, Haraguchi M, Gao H, Gotanda T, Jueng HC, Murata F, Akiyama S. (2005) Characterization of MVP and VPARP assembly into vault ribonucleoprotein complexes. Biochem Biophys Res Commun. 326, 100-107.

van Zon A, Mossink MH, Schoester M, Scheper RJ, Sonneveld P, Wiemer EA. (2004) Efflux kinetics and intracellular distribution of daunorubicin are not affected by major vault protein/lung resistance-related protein (vault) expression. Cancer Res. 64, 4887-4892.

Eichenmuller B, Kedersha N, Solovyeva E, Everley P, Lang J, Himes RH, Suprenant KA. (2003) Vaults bind directly to microtubules via their caps and not their barrels. Cell Motil. Cytoskeleton 56, 225-236.

Mossink MH, van Zon A, Scheper RJ, Sonneveld P, Wiemer EA. (2003) Vaults: a ribonucleoprotein particle involved in drug resistance? Oncogene 22, 7458-7467.

Stam RW, van den Heuvel-Eibrink MM, den Boer ML, Ebus ME, Janka-Schaub GE, Allen JD, Pieters R. (2004) Multidrug resistance genes in infant acute lymphoblastic leukemia: Ara-C is not a substrate for the breast cancer resistance protein. Leukemia 18, 78-83.

van Zon A, Mossink MH, Scheper RJ, Sonneveld P, Wiemer EA. (2003) The vault complex. Cell Mol Life Sci. 60, 1828-1837.

van Zon A, Mossink MH, Schoester M, Houtsmuller AB, Scheffer GL, Scheper RJ, Sonneveld P, Wiemer EA. (2003) The formation of vault-tubes: a dynamic interaction between vaults and vault PARP. J Cell Sci. 116, 4391-400.

Mossink MH, de Groot J, van Zon A, Franzel-Luiten E, Schoester M, Scheffer GL, Sonneveld P, Scheper RJ, Wiemer EA. (2003) Unimpaired dendritic cell functions in MVP/LRP knockout mice. Immunology 110, 58-65.


Rome, L., Kedersha, N. and Chugani, D. (1991) Unlocking vaults: organelles in search of a function. Trends Cell Biol 1, 47-50.

Rome, L.H. (1995) Multidrug resistance: Locked in the Vault? (News & Views) Nature Medicine 1, 527.

Izquierdo, M.A., Scheffer, G.L., Flens, M.J., Shoemaker, R.H., Rome, L.H. and Scheper, R.J. (1996) Relationship of LRP-human major vault protein to in vitro and clinical resistance to anticancer drugs. Cytotechnology 19, 191-197.

Scheper, R.J., Scheffer, G.L., Flens, M.J., van der Valk, P., Meijer, C.J.L.M., Pinedo, H.M., Clevers, H.C., Slovak, M.L., Rome, L.H., Shoemaker, R.H. and Izquierdo, M.A. (1996) Role of LRP-major vault protein in multidrug resistance. In Multidrug Resistance in Cancer Cells: Cellular, Biochemical, Molecular and Biological Aspects, (Sudir Gupta and Takashi Tsuruo eds.) John Wiley & Sons, New York.

Kickhoefer, V.A., Vasu, S., and Rome, L.H. (1996) Vaults are the answer, what is the question? Trends in Cell Biology 6, 174-178.

Suprenant, K.A. (2002). Vault ribonucleoprotein particles: sarcophagi, gondolas, or safety deposit boxes? Biochemistry 41, 14447-14454.

Scheffer, G.L., Schroeijers, A.B., Izquierdo, M.A., Wiemer, E.A., and Scheper, R.J. (2000) Lung resistance-related protein/major vault protein and vaults in multidrug-resistant cancer. Curr Opin Oncol. 12, 550-556.

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