vaults: novel cell particles
Information



Erik A.C. Wiemer, Ph.D.

Vault Researchers Worldwide

Erik A.C. Wiemer, Ph.D. Inst. of Hematology
Erasmus University Rotterdam
Dr. Molewaterplein 50
3015 GE Rotterdam
The Netherlands
Tel: (+31)-10-408 8082
Fax: (+31)-10-408 9474

Email: wiemer@hema.fgg.eur.nl

Erik Wiemer studied Biology at the University of Amsterdam, the Netherlands and the University of Nottingham, UK. From 1985 - 1989. He was a graduate student in the laboratory of Joseph Tager in the Laboratory of Biochemistry / E.C. Slater Institute for Biochemical Research of the University of Amsterdam. Central theme of his research during this time was the biogenesis of peroxisomes in relation to peroxisomal disorders. January 1990 he left the Netherlands for a postdoctoral fellowship at the Christian de Duve Institute of Cellular Pathology in Brussels, Belgium to work in the group of Fred Opperdoes and Paul Michels on the parasitic protozoans. He studied metabolic peculiarities and the evolutionary origins of glycosomes in Trypanosoma brucei and related organisms. In May 1992 he joined the lab of Suresh Subramani at the dept. of Biology of UCSD in La Jolla to work on peroxisome biogenesis in yeast and mammalian cells. In October 1995 he moved to the dept. of Hematology of the Erasmus University Rotterdam in the Netherlands. Currently his main research interest is the molecular mechanisms basis of multidrug resistance. In recent years the possible relation of vaults with multidrug resistance attracted his attention. He now heads a small, but highly motivated, research group investigating the biogenesis and function of vaults. He likes hiking, travelling, reading and entertaining his two daughters (aged 7 and 4).

Selected publications

A.B. Schroeijers, Scheffer, G.L., Reurs, A.W., Pijnenborg, A.C.L.M., Abbondanza, C, Wiemer, E.A.C. and Scheper, R.J. (2001) Detection of the Mr 110,000 lung resistance-related protein LRP/MVP with monoclonal antibodies. J. Histochem. Cytochem. 49, 1379-1385

A.van Zon, Mossink, M.H., Schoester, M., Schroeijers, A.B., Scheffer, G.L., Scheper, R.J., Sonneveld, P. and Wiemer, E.A.C. (2001) Multiple human vault RNAs: expression and association with the vault complex. J. Biol. Chem. 276, 37715-37721

M.M. van den Heuvel-Eibrink, Wiemer, E.A.C., de Boevere, M.J., van der Holt, B., Vossebeld, P.J.M., Pieters, R. and Sonneveld, P. (2001) MDR1 gene-related clonal selection and P-glycoprotein function and expression in relapsed or refractory acute myeloid leukemia. Blood 97(11), 3605-3611

M.M. van den Heuvel-Eibrink, Wiemer, E.A.C., Kuipers, M., Pieters, R. and Sonneveld, P. (2001) Absence of mutations in the deoxycytidine kinase (dCK) gene in patients with relapsed and/or refractory acute myeloid leukemia (AML). Leukemia 15, 855-856

M.M. van den Heuvel-Eibrink, Wiemer, E.A.C., de Boevere, M.J., Slater, R.M., Smit, E.M.E., van Noesel, M.M., van der Holt, B., Schoester, M., Pieters, R. and Sonneveld, P. (2001) MDR1 expression in poor-risk acute myeloid leukemia with partial or complete monosomy 7. Leukemia 15, 398-405

G.L. Scheffer, Schroeijers, A.B., Izquierdo, M.A., Wiemer, E.A.C. and Scheper, R.J. (2000) LRP/MVP and vaults in multidrug resistant cancer. Curr. Opin. Oncol. 12, 550-556

A.B. Schroeijers, Siva, A.C., Scheffer, G.L., de Jong, M.C., Bolick, S.C.E., Dukers, D.F., Slootstra, J.W., Meloen, R.H., Wiemer, E., Kickhoefer, V.A., Rome, L.H. and Scheper, R.J. (2000) The 193 kDa minor vault protein is upregulated in multidrug resistant cancer cell lines. Cancer Res. 60, 1104-1110

P. Sonneveld and Wiemer, E.A.C. (1997) Inhibitors of multidrug resistance. Curr. Opin. Oncol. 9, 543-548

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