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Selected Publications
2009
Tanaka, H., Kato, K., Yamashita, E., Sumizawa, T., Zhou, Y., Yao, M., Iwasaki, K., Yoshimura, M., Tsukihara, T.
The structure of rat liver vault at 3.5 angstrom resolution
Science, 323(5912): 384-8 (2009)
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[Supplemental Material]
Kickhoefer, V.A., Han, M., Raval-Fernandes, S., Poderycki, M.J., Moniz, R.J., Vaccari, D., Silvestry, M., Stewart, P.L., Kelly, K.A., Rome, L.H.
Targeting vault nanoparticles to specific cell surface receptors
ACS Nano, 3(1): 27-36 (2009)
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Lai, C.Y., Wiethoff, C.M., Kickhoefer, V.A., Rome, L.H., Nemerow, G.R.
Vault nanoparticles containing an adenovirus-derived membrane lytic protein facilitate toxin and gene transfer
ACS Nano Feb 18, 2009 Ahead of print
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2008
Ng, B.C., Yu, M., Gopal, A., Rome, L.H., Monbouquette, H.G., Tolbert, S.H.
Encapsulation of semiconducting polymers in vault protein cages
Nano Lett., 8(10): 3503-9 (2008)
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Yu, M., Ng, B.C., Rome, L.H., Tolbert, S.H., Monbouquette, H.G.
Reversible pH lability of cross-linked vault nanocapsules
Nano Lett., 8(10): 3510-5 (2008)
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Esfandiary, R., Kickhoefer, V.A., Rome, L.H., Joshi, S.B., Middaugh, C.R.
Structural stability of vault particles
J. Pharm. Sci., 98(4): 1376-86 (2008)
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2007
Anderson, D.H., Kickhoefer, V.A., Sievers, S.A., Rome, L.H., Eisenberg, D.
Draft crystal structure of the vault shell at 9-Å resolution
PLoS Biology, 11(5): 2661-70 (2007)
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Goldsmith, L.E., Yu, M., Rome, L.H., Monbouquette, H.G.
Vault nanocapsule dissociation into halves triggered at low pH
Biochemistry, 46(10): 2865-75 (2007)
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Mrazek, J., Kreutmayer, S.B., Grasser, F.A., Polacek, N., Huttenhofer, A.
Subtractive hybridization identifies novel differentially expressed ncRNA species in EBV-infected human B cells
Nucleic Acids Res., 35(10): e73 (2007)
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Kaddis, C.S., Lomeli, S.H., Yin, S., Berhane, B., Apostol, M.I., Kickhoefer, V.A., Rome, L.H., Loo, J.A.
Sizing large proteins and protein complexes by electrospray ionization mass spectrometry and ion mobility
J. Am. Soc. Mass Spectrom., 18(7): 1206-16 (2007)
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Kowalski, M.P., Dubouix-Bourandy, A., Bajmoczi, M., Golan, D.E., Zaidi, T., Coutinho-Sledge, Y.S., Gygi, M.P., Gygi, S.P., Wiemer, E.A.C., Pier, G.B.
Host resistance to lung infection mediated by major vault protein in epithelial cells
Science, 317(5834): 130-2 (2007)
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[Supplemental Material]
2006
Poderycki, M.J., Kickhoefer, V.A., Kaddis, C.S., Raval-Fernandes, S., Johansson, E., Zink, J.I., Loo, J.A., Rome, L.H.
The vault exterior shell is a dynamic structure that allows incorporation of vault-associated proteins into its interior
Biochemistry, 45(39): 12184-93 (2006)
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Slesina, M., Inman, E.M., Moore, A.E., Goldhaber, J.I., Rome, L.H., Volknandt, W.
Movement of vault particles visualized by GFP-tagged major vault protein
Cell Tissue Res., 324(3): 403-10 (2006)
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van Zon, A., Mossink, M.H., Houtsmuller, A.B., Schoester, M., Scheffer, G.L., Scheper, R.J., Sonneveld, P., Wiemer, E.A.
Vault mobility depends in part on microtubules and vaults can be recruited to the nuclear envelope
Exp. Cell Res., 312(3): 245-55 (2006)
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Steiner, E., Holzmann, K., Pirker, C., Elbling, L., Micksche, M., Sutterluty, H., Berger, W.
The major vault protein is responsive to and interferes with interferon-gamma-mediated STAT1 signals
J. Cell Sci., 119(Pt.3): 459-69 (2006)
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Kim, E., Lee, S., Mian, M.F., Yun, S.U., Song, M., Yi, K.S., Ryu, S.H., Suh, P.G.
Crosstalk between Src and major vault protein in epidermal growth factor-dependent cell signaling
FEBS J., 273(4): 793-804 (2006)
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Kozlov, G., Vavelyuk, O., Minailiuc, O., Banville, D., Gehring, K., Ekiel, I.
Solution structure of a two-repeat fragment of major vault protein
J. Mol. Biol., 356(2): 444-52 (2006)
2005
Raval-Fernandes, S., Kickhoefer, V.A., Kitchen, C., Rome, L.H.
Increased susceptibility of vault poly(ADP-ribose) polymerase deficient mice to carcinogen-induced tumorigenesis
Cancer Res., 65(19): 8846-52 (2005)
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Kickhoefer, V.A., Garcia, Y., Mikyas, Y., Johansson, E., Zhou, J.C., Raval-Fernandes, S., Minoofar, P., Zink, J.I., Dunn, B., Stewart, P.L., Rome, L.H.
Engineering of vault nanocapsules with enzymatic and fluorescent properties
PNAS, 102(12): 4348-52 (2005)
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Poderycki, M.J., Rome, L.H., Harrington, L., Kickhoefer, V.A.
The p80 homology region of TEP1 is sufficient for its association with the telomerase and vault RNAs, and the vault particle
Nucleic Acids Res., 33(3): 893-902 (2005)
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Slesina, M., Inman, E.M., Rome, L.H., Volknandt, W.
Nuclear localization of the major vault protein in U373 cells
Cell Tissue Res., 321(1): 97-104 (2005)
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Yi, C., Li, S., Chen, X., Wiemer, E.A., Wang, J., Wei, N., Deng, X.W.
Major vault protein, in concert with constitutively photomorphogenic 1, negatively regulates c-Jun-mediated activator protein 1 transcription in mammalian cells
Cancer Res., 65(13): 5835-40 (2005)
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Zheng, C.L., Sumizawa, T., Che, X.F., Tsuyama, S., Furukawa, T., Haraguchi, M., Gao, H., Gotanda, T., Jueng, H.C., Murata, F., Akiyama, S.
Characterization of MVP and VPARP assembly into vault ribonucleoprotein complexes
Biochem. Biophys. Res. Commun., 326(1): 100-7 (2005)
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Stewart, P.L., Makabi, M., Lang, J., Dickey-Sims, C., Robertson, A.J., Coffman, J.A., Suprenant, K.A.
Sea urchin vault structure, composition, and differential localization during development
BMC Dev. Biol., 5:3 (2005)
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Huffman, K.E., Corey, D.R.
Major vault protein does not play a role in chemoresistance or drug localization in a non-small cell lung cancer cell line
Biochemistry, 44(7): 2253-61 (2005)
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2004
Mikyas, Y., Makabi, M., Raval-Fernandes, S., Harrington, L., Kickhoefer, V.A., Rome, L.H., Stewart, P.L.
Cryoelectron microscopy imaging of recombinant and tissue derived vaults: localization of the MVP N termini and VPARP
J. Mol. Biol., 344(1): 91-105 (2004)
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Emre, N., Raval-Fernandes, S., Kickhoefer, V.A., Rome, L.H.
Analysis of MVP and VPARP promoters indicates a role for chromatin remodeling in the regulation of MVP
Biochim. Biophys. Acta., 1678(1): 33-46 (2004)
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Liu, Y., Snow, B.E., Kickhoefer, V.A., Erdmann, N., Zhou, W., Wakeham, A., Gomez, W., Rome, L.H., Harrington, L.
Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivo
Mol. Cell. Biol., 24(12): 5314-23 (2004)
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Kolli, S., Zito, C.I., Mossink, M.H., Wiemer, E.A., Bennett, A.M.
The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling
J. Biol. Chem., 279(28): 29374-85 (2004)
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Steiner, E., Holzmann, K., Pirker, C., Elbling, L., Micksche, M., Berger, W.
SP-transcription factors are involved in basal MVP promoter activity and its stimulation by HDAC inhibitors
Biochem. Biophys. Res. Commun., 317(1): 235-43 (2004)
van Zon, A., Mossink, M.H., Schoester, M., Scheper, R.J., Sonneveld, P., Wiemer, E.A.
Efflux kinetics and intracellular distribution of daunorubicin are not affected by major vault protein/lung resistance-related protein (vault) expression
Cancer Res., 64(14): 4887-92 (2004)
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2003
Kickhoefer, V.A., Emre, N., Stephen, A., Poderycki, M., Rome, L.H.
Identification of conserved vault RNA expression elements and a non-expressed mouse vault RNA gene
Gene, 309(2): 65-70 (2003)
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Eichenmuller, B., Kedersha, N., Solovyeva, E., Everley, P., Lang, J., Himes, R.H., Suprenant, K.A.
Vaults bind directly to microtubules via their caps and not their barrels
Cell Motil. Cytoskeleton, 56(4): 225-36 (2003)
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Mossink, M.H., van Zon, A., Scheper, R.J., Sonneveld, P., Wiemer, E.A.
Vaults: a ribonucleoprotein particle involved in drug resistance?
Oncogene, 22(47): 7458-67 (2003)
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van Zon, A., Mossink, M.H., Scheper, R.J., Sonneveld, P., Wiemer, E.A.
The vault complex
Cell Mol. Life Sci., 60(9): 1828-37 (2003)
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van Zon, A., Missink, M.H., Schoester, M., Houtsmuller, A.B., Scheffer, G.L., Scheper, R.J., Sonneveld, P., Wiemer, E.A.
The formation of vault-tubes: a dynamic interaction between vaults and vault PARP
J. Cell Sci., 116(Pt.21): 4391-400 (2003)
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Mossink, M.H., de Groot, J., van Zon, A., Fränzel-Luiten, E., Schoester, M., Scheffer, G.L., Sonneveld, P., Scheper, R.J., Wiemer, E.A.
Unimpaired dendritic cell functions in MVP/LRP knockout mice
Immunology, 110(1): 58-65 (2003)
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2002
Kickhoefer, V.A., Poderycki, M.J., Chan, E.K., Rome, L.H.
The La RNA-binding protein interacts with the vault RNA and is a vault-associated protein
J. Biol. Chem., 277(43): 41282-6 (2002)
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Yu, Z., Fotouhi-Ardakani, N., Wu, L., Maoui, M., Wang, S., Banville, D., Shen, S.H.
PTEN associates with the vault particles in HeLa cells
J. Biol. Chem., 277(43): 40247-52 (2002)
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Scheffer, G.L., Pijnenborg, A.C., Smit, E.F., Muller, M., Postma, D.S., Timens, W., van der Valk, P., de Vries, E.G., Scheper, R.J.
Multidrug resistance related molecules in human and murine lung
J. Clin. Pathol., 55(5): 332-9 (2002)
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van Zon, A., Mossink, M.H., Schoester, M., Scheffer, G.L., Scheper, R.J., Sonneveld, P., Wiemer, E.A.
Structural domains of vault proteins: a role for the coiled coil domain in vault assembly
Biochem. Biophys. Res. Commun., 291(3): 535-41 (2002)
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Schoreijers, A.B., Reurs, A.W., Scheffer, G.L., Stam, A.G., de Jong, M.C., Rustemeyer, T., Wiemer, E.A., de Gruijl, T.D., Scheper, R.J.
Up-regulation of drug resistance-related vaults during dendritic cell development
J. Immunol., 168(4): 1572-8 (2002)
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Mossink, M.H., van Zon, A., Fränzel-Luiten, E., Schoester, M., Kickhoefer, V.A., Scheffer, G.L., Scheper, R.J., Sonneveld, P., Wiemer, E.A.
Disruption of the murine major vault protein (MVP/LRP) gene does not induce hypersensitivity to cytostatics
Cancer Res., 62(24): 7298-304 (2002)
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Hu, Y., Stephen, A.G., Cao, J., Tanzer, L.R., Slapak, C.A., Harrison, S.D., Devanaravan, V., Dantzig, A.H., Starling, J.J., Rome, L.H., Moore, R.E.
A very early induction of major vault protein accompanied by increased drug resistance in U-937 cells
Int. J. Cancer, 97(2): 149-56 (2002)
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2001
Stephen, A.G., Raval-Fernandes, S., Huynh, T., Torres, M., Kickhoefer, V.A. and Rome, L.H.
Assembly of vault-like particles in insect cells expressing only the major vault protein
J. Biol. Chem., 276(26): 23217-20 (2001)
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Kickhoefer, V.A., Liu, Y., Kong, L.B., Snow, B.E., Stewart, P.L , Harrington, L., and Rome, L.H.
The telomerase/vault-associated protein TEP1 is required for vault RNA stability and its association with the vault particle
J. Cell Biol., 152(1): 157-64 (2001)
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Siva, A.C., Raval-Fernandes, S., Stephen, A.G., LaFemina, M.J., Scheper, R.J., Kickhoefer, V.A., Rome, L.H.
Upregulation of vaults may be necessary but not sufficient for multidrug resistance
Int. J. Cancer, 92(2): 195-202 (2001)
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Schroeijers, A.B., Scheffer, G.L., Reurs, A.W., Pijnenborg, A.C., Abbondanza, C., Wiemer, E.A., Scheper, R.J.
Detection of the Mr 110,000 lung resistance-related protein LRP/MVP with monoclonal antibodies
J. Histochem. Cytochem., 49(11): 1379-85 (2001)
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van Zon, A., Mossink, M.H., Schoester, M., Scheffer, G.L., Scheper, R.J., Sonneveld, P., Wiemer, E.A.
Multiple human vault RNAs. Expression and association with the vault complex
J. Biol. Chem., 276(40): 37715-21 (2001)
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Holzmann, K., Ambrosch, I., Elbling, L., Micksche, M., Berger, W.
A small upstream open reading frame causes inhibition of human major vault protein expression from a ubiquitous mRNA splice variant
FEBS Lett., 494(1-2): 99-104 (2001)
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